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Leslie O'Brien, Baron O'Brien of Lothbury GBE PC (8 February 1908 – 24 November 1995) was Governor of the Bank of England.

After attending Wandsworth Grammar School in London, he joined the Bank of England in 1927 and rose through the ranks, becoming chief cashier in 1955, deputy governor in 1966, before serving as governor from 1966 until 1973. As governor, O'Brien presided over the devaluation of the pound in 1967.